Please confirm that you are running version 10 (build 10.0.0.4461) prior to installing this update. You can check this under Help | About in the Veeam Backup & Replication console. After upgrade, your build number will be 10.0.0.4461 P1.
Cloud Connect users: This patch is not compatible with the Cloud Connect infrastructure based on the RTM build 10.0.0.4442. Please confirm with your service provider that they are using the GA build 10.0.0.4461 (any patch level) prior to upgrading!