Challenge
Veeam will cause additional IOPS on the datastore of the source VM (and a target VM, in a replication job) potentially impacting other VMs in the same datastore.
In some cases this may cause the performance of other neighboring VMs (on the same datastore) to decrease during this heavy I/O period.
Solution
This heavy I/O may be either the result of a Veeam backup or conversely, may negatively impact the performance of a Veeam backup. If some VM(s) (not being backed up) is monopolizing the datastore with heavy I/O this may cause Veeam to have small slice of the disk I/O available during backup processes.
This is not specific to Veeam and the issue can be addressed by VMware by use of Storage I/O Control (SIOC).
Note: The Storage I/O Control feature requires VMware Enterprise Plus licensing.
http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1022091
SIOC is actually using a congestion algorithm to determine a normal latency for storage devices in a datastore and then spread this evenly across all VMs to assure an equal share of the available IOPS for each device.
More Information
SIOC protects all virtual machines from unwarranted negative performance impact due to I/O-heavy virtual machines. SIOC prevents a single virtual machine from monopolizing the I/O throughput of a datastore. Storage I/O Control (SIOC) was introduced in vSphere 4.
Storage I/O Control Technical Overview and Considerations for Deployment http://www.vmware.com/files/pdf/techpaper/VMW-vSphere41-SIOC.pdf
SIOC cannot be controlled within a Veeam job, but merely is part of a well-designed VMware environment that will be taken advantage of by Veeam.
Other Related links:
Dynamically Allocate I/O Capacity Across Multiple Hosts - See more at: http://www.vmware.com/products/vsphere/features/storage-io-control.html#sthash.uJXpAGGZ.dpuf
Unmanaged I/O workload detected on shared datastore running Storage I/O Control (SIOC) for congestion management (1020651) http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1020651
Troubleshooting Storage I/O Control (1022091) http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1022091