This Affects All Traffic to the Modified Region
The AmazonS3Regions.xml file contains a list of regions and their respective endpoints. Modifying a region's endpoints makes it possible to force Veeam Backup & Replication to connect to a specific endpoint when that region is selected in the UI. This modification will cause all tasks that utilize the region you modify to employ the customized S3 and EC2 endpoints. If you wish to avoid interference, consider altering a region that other tasks or objects in Veeam Backup & Replication are not using. Then, use that altered region exclusively when you want to direct traffic to use the custom endpoints.